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Charleston · Hotel shortlist

The best hotels near MUSC Health University Medical Center

Peter Halvorsen

Peter Halvorsen The Nordics

Updated 1 September 2026 · 74 Charleston hotels assessed

These are my five favourites in Charleston, out of the 74 that qualified. I read what other travellers scored them before I picked, so the order follows the guests, 4.9 down to 4.8.

All five are within 2.0 km of MUSC Health University Medical Center.

The Iris

Highest rated of the five

The Iris

★★★★★4.9 from 398 reviews

The Iris comes out on top of this list, and not narrowly: 4.9 from 398 guest reviews is a score that holds up at that volume, which is the whole test here. A perfect ten from nine people does not beat it.

It is a 5 star property, found under poi and around $329 a night on the dates we checked.

74 hotels in Charleston qualified for this list and five made it. Wentworth Mansion is the one I would book if the first is full.

Why it works for this trip

  • Spatreatment rooms on site, no booking a taxi for it
  • Air conditioningthe one that decides a summer trip
  • Family roomscots and larger rooms rather than a squeeze
  • Kitchenettebreakfast on your own schedule
  • Parkinga real consideration if you are driving in

Check rates Read more

All five, ranked

  1. The Iris1

    The Iris

    ★★★★★4.9 from 398 reviews

    1.2 km from MUSC Health University Medical Center, about a 15 minute walk

    • Spa
    • Parking
    • Kitchen
    • Pet friendly
    • Kid friendly
    • Air conditioning

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  2. Wentworth Mansion2

    Wentworth Mansion

    ★★★★★4.8 from 499 reviews

    1.0 km from MUSC Health University Medical Center, about a 12 minute walk

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    • The Inns Charleston3

      The Inns Charleston

      ★★★★★4.9 from 343 reviews

      900 m from MUSC Health University Medical Center, about a 11 minute walk

      • Parking

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    • The Loutrel4

      The Loutrel

      ★★★★★4.9 from 378 reviews

      2.0 km from MUSC Health University Medical Center, about a 25 minute walk

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      • The Pinch Charleston5

        The Pinch Charleston

        ★★★★★4.9 from 305 reviews

        1.4 km from MUSC Health University Medical Center, about a 18 minute walk

          Check rates Read more

        How this list was put together

        74 Charleston hotels qualify for this list. We ranked them on guest rating first and on how close they are to MUSC Health University Medical Center second, then took the top five.

        Two things decide these lists. The first is my own time in the city: every hotel on this page is one I have stayed in, walked into and looked at, or gone back to check. That is where the shortlist starts, and it is why some well reviewed places are not on it.

        The second is the numbers, and those are what set the order. The rating and review count come from the big travel sites, pooled through Google, so a score here reflects Expedia, Booking, Hotels.com and the rest together rather than any one of them. I also read the review breakdown by topic, which is where the figures on service, breakfast and location come from. Hotels with fewer than forty reviews are left out altogether, because a rating that thin is not a rating. No more than two come from one neighbourhood.

        What I do not do is move anyone up the order. The ranking is the guest score, highest first, and nobody pays to be on the list.

        Distances are straight lines from published coordinates, so the real walk is a little longer. Amenities are as recorded by Google Hotels and can change without notice. Rates are an indicative nightly figure for a midweek autumn stay, not a quote. Check the booking page before you commit.

        Peter Halvorsen

        Peter Halvorsen The Nordics

        Twenty-six years of teaching means 26 long summers. Trains and driving through most of Europe, now further afield, usually alone with a tent. Keeps every train ticket since 1994.

        Trip Grapevine earns a commission on bookings made through the links on this page. It costs you nothing, and it does not change the order of the list, which is set by the measurements above.